KCNQ2 Polyclonal Antibody

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£195.30

War £217.00

SKU:: E-AB-92142
Zusätzliche Namen:: BFNC,EBN,EBN1,ENB1,HNSPC,KCNA11,KCNQ2,KV7.2
Anwendung:: WB
Konzentration:: 1 mg/ml
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human KCNQ2
Uniprot:: O43526
Synonyme:: BFNC;DEE7;EBN;EBN1;ENB1;HNSPC;KCNA11;KQT-like 2;KV7.2;neuroblastoma-specific potassium channel subunit alpha KvLQT2;potassium channel, voltage gated KQT-like subfamily Q, member 2;potassium voltage-gated channel subfamily KQT member 2;voltage-gated potassium channel subunit Kv7.2
Weitere Details:: The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.