PANK2 Polyclonal Antibody

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£195.30

War £217.00

SKU:: E-AB-92074
Zusätzliche Namen:: C20orf48,HARP,HSS,NBIA1,PANK2,PKAN
Anwendung:: WB
Konzentration:: 1 mg/ml
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Mouse
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: A synthetic peptide of human PANK2
Uniprot:: Q9BZ23
Synonyme:: C20orf48;Hallervorden-Spatz syndrome;HARP;HSS;NBIA1;pantothenate kinase 2, mitochondrial;pantothenate kinase-associated neurodegeneration;pantothenic acid kinase 2;PKAN
Weitere Details:: This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]