ZFPM1 Polyclonal Antibody

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£195.30

War £217.00

SKU:: E-AB-91990
Zusätzliche Namen:: FOG,FOG1,ZC2HC11A,ZFPM1,ZNF408,ZNF89A
Anwendung:: WB, IF
Konzentration:: 1 mg/ml
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human ZFPM1
Uniprot:: Q8IX07
Synonyme:: FOG;FOG-1;FOG1;friend of GATA 1;friend of GATA protein 1;ZC2HC11A;zinc finger protein 89A;Zinc finger protein multitype 1;zinc finger protein ZFPM1;zinc finger protein, multitype 1;ZNF408;ZNF89A
Weitere Details:: Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity.