E-AB-91664
PNN Polyclonal Antibody
Größe
£195.30
War £217.00
- SKU:
- E-AB-91664
- Zusätzliche Namen:
- DRS,DRSP,PNN,SDK3,memA,pinin
- Anwendung:
- WB
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- A synthetic peptide of human PNN
- Uniprot:
- Q9H307
- Synonyme:
- 140 kDa nuclear and cell adhesion-related phosphoprotein;desmosome-associated protein;domain-rich serine protein;DRS;DRSP;melanoma metastasis clone A protein;memA;neutrophil protein;nuclear protein SDK3;pinin;SDK3;SR-like protein
- Weitere Details:
- Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene, the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma.
- Versandbedingungen:
- Blue Ice