PPM1F Polyclonal Antibody

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£195.30

War £217.00

SKU:: E-AB-91134
Zusätzliche Namen:: CAMKP,CaMKPase,FEM-2,POPX2,PPM1F,hFEM-2
Anwendung:: WB
Konzentration:: 1 mg/ml
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human PPM1F
Uniprot:: P49593
Synonyme:: Ca(2+)/calmodulin-dependent protein kinase phosphatase;CaM-kinase phosphatase;CAMKP;CaMKPase;FEM-2;hFEM-2;partner of PIX 2;POPX2;PP2C phosphatase;protein fem-2 homolog;protein phosphatase 1F;protein phosphatase 1F (PP2C domain containing)
Weitere Details:: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined.