EBF1 Polyclonal Antibody

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£195.30

War £217.00

SKU:: E-AB-90481
Zusätzliche Namen:: COE1,EBF,EBF1,O/E-1,OLF1
Anwendung:: WB
Konzentration:: 1 mg/ml
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: A synthetic peptide of human EBF1
Uniprot:: Q9UH73
Synonyme:: COE1;Collier, Olf and EBF transcription factor 1;early B cell factor 1;Early B-cell factor;EBF;O/E-1;OLF1;olfactory neuronal transcription factor 1;transcription factor COE1
Weitere Details:: Key pioneer transcription factor of B-cell specification and commitment. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Operates in a transcription factor network to activate B-cell-specific genes and repress genes associated with alternative cell fates. For instance, positively regulates many B-cell specific genes including BCR or CD40 while repressing genes that direct cells into alternative lineages, including GATA3 and TCF7 for the T-cell lineage. In addition to its role during lymphopoiesis, controls the thermogenic gene program in adipocytes during development and in response to environmental cold (By similarity.