GRM1 Polyclonal Antibody

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£195.30

War £217.00

SKU:: E-AB-90267
Zusätzliche Namen:: GPRC1A,GRM1,MGLU1,MGLUR1,PPP1R85,SCAR13
Anwendung:: WB
Konzentration:: 1 mg/ml
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human GRM1
Uniprot:: Q13255
Synonyme:: glutamate receptor, metabotropic 1;GPRC1A;metabotropic glutamate receptor 1;MGLU1;MGLUR1;PPP1R85;protein phosphatase 1, regulatory subunit 85;SCA44;SCAR13
Weitere Details:: This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.