E-AB-90029
AIF Polyclonal Antibody
Größe
£311.40
War £346.00
- SKU:
- E-AB-90029
- Zusätzliche Namen:
- AIF,AIFM1,CMT2D,CMTX4,COWCK,COXPD6,DFNX5,NADMR,NAMSD,PDCD8
- Anwendung:
- IHC, WB, IF
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human AIF
- Uniprot:
- O95831
- Synonyme:
- AIF;apoptosis-inducing factor 1, mitochondrial;apoptosis-inducing factor, mitochondrion-associated, 1;auditory neuropathy, X-linked recessive 1;AUNX1;CMT2D;CMTX4;COWCK;COXPD6;DFNX5;NADMR;NAMSD;PDCD8;programmed cell death 8 (apoptosis-inducing factor);Programmed cell death protein 8;SEMDHL;striatal apoptosis-inducing factor;testicular secretory protein Li 4
- Weitere Details:
- This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and mental retardation. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10.
- Versandbedingungen:
- Blue Ice