E-AB-90007
BCL2A1 Polyclonal Antibody
Größe
£195.30
War £217.00
- SKU:
- E-AB-90007
- Zusätzliche Namen:
- ACC-1,ACC-2,ACC1,ACC2,BCL2A1,BCL2L5,BFL1,GRS,HBPA1
- Anwendung:
- IF
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- A synthetic peptide of human BCL2A1
- Uniprot:
- Q16548
- Synonyme:
- ACC-1;ACC-2;ACC1;ACC2;bcl-2-like protein 5;bcl-2-related protein A1;bcl2-L-5;BCL2L5;BFL1;GRS;HBPA1;hematopoietic BCL2-related protein A1;hemopoietic-specific early response protein;protein BFL-1;Protein GRS
- Weitere Details:
- This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
- Versandbedingungen:
- Blue Ice