Recombinant Ubiquitin K63 Monoclonal Antibody

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£178.20

War £198.00

SKU:: E-AB-81618
Zusätzliche Namen:: UBB,Ubiquitin
Anwendung:: IHC, WB, IHC-P, IF
Konzentration:: 300 ug/ml
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human
Buffer:: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% stabilizer and 0.05% protective protein.
Immunogen:: A synthetic peptide of human Ubiquitin (linkage-specific K63)
Klon:: R06-2H7
Uniprot:: P0CG47
Synonyme:: epididymis secretory protein Li 50;HEL-S-50;polyubiquitin B;polyubiquitin-B
Weitere Details:: This gene encodes ubiquitin, one of the most conserved proteins known.Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover.Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation.Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression.This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence.Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat.Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome.