E-AB-70253
PPARA Polyclonal Antibody
Größe
£178.20
War £198.00
- SKU:
- E-AB-70253
- Zusätzliche Namen:
- MGC2237,MGC2452,NR1C1,Nuclear receptor subfamily 1 group C member 1,OTTHUMP00000197740,OTTHUMP00000197741,Peroxisome proliferative activated receptor alpha,Peroxisome proliferator activated receptor alpha,Peroxisome proliferator-activated receptor a,hPPAR
- Anwendung:
- IHC
- Konzentration:
- 0.6 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 1% protein protectant and 50% glycerol.
- Immunogen:
- KLH conjugated Synthetic peptide corresponding to Mouse PPARA Alpha
- Uniprot:
- P23204, P37230
- Synonyme:
- 4933429D07Rik;AW742785;Nr1;Nr1c1;nuclear receptor subfamily 1 group C member 1;P;peroxisome proliferator-activated receptor alpha;PP;Ppar;PPAR-alpha;PPARalpha
- Weitere Details:
- Peroxisome proliferator-activated receptor alpha (PPARA) is a ligand-activated transcription factor that belongs to the PPAR nuclear receptor superfamily. PPARA is essential in the modulation of lipid transport and metabolism, mainly through activating mitochondrial and peroxisomal fatty acid B Beta-oxidation pathways. In addition, PPARA seems to decrease inflammation mainly through direct interaction with NF-K KappaB, causing inhibition of its signaling pathway or reducing the activated levels of NF-K KappaB and subsequent inflammation. Furthermore, PPARA was implicated in the attenuation of oxidative stress in alcoholic liver disease when treated with polyenephosphatidylcholine through downregulation of ROS-generating enzymes such as ethanol-inducible cytochrome P450 2E1 (CYP2E1), acyl-CoA oxidase, and NADPH oxidase.
- Versandbedingungen:
- Blue Ice