E-AB-70143
FOXO1 Polyclonal Antibody
Größe
£178.20
War £198.00
- SKU:
- E-AB-70143
- Zusätzliche Namen:
- Drosophila,FKH 1,FKH1,FKHR,FOXO1,Forkhead,Forkhead (Drosophila) homolog 1 (rhabdomyosarcoma),Forkhead box O1,Forkhead box protein O1,Forkhead box protein O1A,Forkhead in rhabdomyosarcoma,FoxO transcription factor,foxo1,homolog of,in rhabdomyosarcoma
- Anwendung:
- WB
- Konzentration:
- 0.58 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 1% protein protectant and 50% glycerol.
- Immunogen:
- Recombinant protein corresponding to Mouse FOXO1
- Uniprot:
- G3V7R4, Q9R1E0
- Synonyme:
- Afx;Afxh;AI876417;FKH;FKHR;Fkhr1;forkhead box O1a;forkhead box O1A (rhabdomyosarcoma);forkhead box protein O1;forkhead box protein O1A;forkhead in rhabdomyosarcoma;forkhead protein 1;Fox;Foxo1a
- Weitere Details:
- FOXO1,also named as FOXO1A,FKHR and FKH1,is a member of the FOXO subfamily of Forkhead transcription factors. FOXO1 is a transcription factor which acts as a regulator of cell responses to oxidative stress. FOXO1 interacts with LRPPRC and SIRT1. In the presence of KIRT1,FOXO1 mediates down-regulation of cyclin D1 and up-regulation of CDKN1B levels which are required for cell transition from proliferative growth to quiescence. FOXO1 contains three predicted protein kinase B phosphorylation sites (Thr-24,Ser-256,and Ser-319) that are conserved in other FOXO proteins. The t(2,13) and the variant t(1,13) translocations generate PAX3/FKHR and PAX7/FKHR fusion proteins respectively. The resulting protein is a transcriptional activator. Defects in FOXO1 are a cause of rhabdomyosarcoma type 2 (RMS2).
- Versandbedingungen:
- Blue Ice