E-AB-70100
CDK4 Polyclonal Antibody
Größe
£178.20
War £198.00
- SKU:
- E-AB-70100
- Zusätzliche Namen:
- CDK4,CDK4 protein,CMM 3,CMM3,Cdk 4,Cell division kinase 4,Cell division protein kinase 4,Crk3,Cyclin dependent kinase 4,Cyclin-dependent kinase 4,MGC14458,Melanoma cutaneous malignant 3,PSK J3,PSK-J3,cdk4,p34 cdk4
- Anwendung:
- IHC
- Konzentration:
- 210 ug/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 1% protein protectant and 50% glycerol.
- Immunogen:
- KLH conjugated Synthetic peptide corresponding to Mouse CDK4
- Uniprot:
- P11802, P30285, P35426
- Synonyme:
- cell division protein kinase 4;CMM3;Crk;Crk3;cyclin-dependent kinase 4;p34<PSK-J3>/cdk4;PSK-J3;serine/threonine kinase
- Weitere Details:
- The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.
- Versandbedingungen:
- Blue Ice