E-AB-70068
p21 Polyclonal Antibody
Größe
£178.20
War £198.00
- SKU:
- E-AB-70068
- Zusätzliche Namen:
- CAP20,CDK-interacting protein 1,CDKI,CDKN1,CDN1A,CIP1,Cdkn1a,Cip1),Cyclin Dependent Kinase Inhibitor 1A,Cyclin-dependent kinase inhibitor 1,Cyclin-dependent kinase inhibitor 1A (P21),Cyclin-dependent kinase inhibitor 1A (p21,DNA Synthesis Inhibitor,MDA-6
- Anwendung:
- IHC
- Konzentration:
- 0.7 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 1% protein protectant and 50% glycerol.
- Immunogen:
- KLH conjugated Synthetic peptide corresponding to Mouse P21
- Uniprot:
- P38936, P39689
- Synonyme:
- CAP;CAP20;CDK;CDK-interacting protein 1;CDK-interaction protein 1;CDKI;Cdkn;CDKN1;CI;CIP1;cyclin-dependent kinase inhibitor 1;cyclin-dependent kinase inhibitor 1A (p21, Cip1);DNA synthesis inhibitor;mda;MDA-6;mda6;melanoma differentiation associated protein 6;melanoma differentiation-associated protein;Melanoma differentiation-associated protein 6;P2;P21;p21C;p21CIP1;p21W;p21WAF;SD;SDI1;Waf;WAF1;wild-type p53-activated fragment 1
- Weitere Details:
- CDKN1A (p21,CIP1,WAF1),a cyclin-dependent kinase inhibitor,is necessary for proper control of the cell cycle and premature senescence. P21 is a cyclin-dependent kinase (CDK) inhibitor that suppresses proliferation by inhibiting CDK2 and CDK1 activity at the G1/S and G2/M transitions. P21 is a major mediator of p53 to induce cell cycle arrest in G1. p21 can interact with proliferating cell nuclear antigen (PCNA),and plays a regulatory role in S phase DNA replication and DNA damage repair. P21 was reported to be specifically cleaved by CASP3-like caspases,which thus leads to a dramatic activation of CDK2,and may be instrumental in the execution of apoptosis following caspase activation. Overexpression of p21 decreases the expression levels of cell cycle progression genes and upregulates senescence-inducing genes.
- Versandbedingungen:
- Blue Ice