CTSC Polyclonal Antibody

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£195.30

War £217.00

SKU:: E-AB-68422
Zusätzliche Namen:: CPPI,CTSC,DPP-I,DPP1,DPPI,HMS,JP,JPD,PALS,PDON1,PLS
Anwendung:: IF
Konzentration:: 1 mg/ml
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Mouse
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human CTSC
Uniprot:: P53634
Synonyme:: Cathepsin C;cathepsin J;CPPI;dipeptidyl peptidase 1;Dipeptidyl peptidase I;dipeptidyl transferase;dipeptidyl-peptidase I;DPP-I;DPP1;DPPI;HMS;JP;JPD;PALS;PDON1;PLS
Weitere Details:: This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. A portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis.