F11R Polyclonal Antibody

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£195.30

War £217.00

SKU:: E-AB-68286
Zusätzliche Namen:: CD321,F11R,JAM,JAM1,JAMA,JCAM,KAT,PAM-1
Anwendung:: IHC, WB
Konzentration:: 1 mg/ml
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human F11R
Uniprot:: Q9Y624
Synonyme:: CD321;JAM;JAM1;JAMA;JCAM;junctional adhesion molecule 1;junctional adhesion molecule A;KAT;PAM-1;platelet adhesion molecule 1;platelet F11 receptor
Weitere Details:: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established.