E-AB-67995
ULk1 Polyclonal Antibody
Größe
£195.30
War £217.00
- SKU:
- E-AB-67995
- Zusätzliche Namen:
- ATG1,ATG1A,ULK1,ULk1,UNC51,Unc51.1,hATG1
- Anwendung:
- WB, IF
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human ULk1
- Uniprot:
- O75385
- Synonyme:
- ATG1;ATG1 autophagy related 1 homolog;ATG1A;autophagy-related protein 1 homolog;hATG1;serine/threonine-protein kinase ULK1;Unc-51-like kinase 1;UNC51;Unc51.1
- Weitere Details:
- Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1 via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR, however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy. Phosphorylates FLCN, promoting autophagy. Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation.
- Versandbedingungen:
- Blue Ice