BNP Polyclonal Antibody

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£195.30

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SKU:: E-AB-67421
Zusätzliche Namen:: BNP,NPPB
Anwendung:: WB, IF
Konzentration:: 1 mg/ml
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human BNP (NP_002512.1).
Uniprot:: P16860
Synonyme:: BNP;brain natriuretic factor prohormone;brain type natriuretic peptide;gamma-brain natriuretic peptide;Iso-ANP;natriuretic peptide precursor B;natriuretic peptides B;natriuretic protein;preproBNP;proBNP
Weitere Details:: This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis.