E2F1 Polyclonal Antibody

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£195.30

War £217.00

SKU:: E-AB-67402
Zusätzliche Namen:: E2F-1,E2F1,RBAP1,RBBP3,RBP3
Anwendung:: IF
Konzentration:: 1 mg/ml
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: A synthetic peptide of human E2F1
Uniprot:: Q01094
Synonyme:: E2F-1;PBR3;PRB-binding protein E2F-1;RBAP-1;RBAP1;RBBP-3;RBBP3;RBP3;retinoblastoma-associated protein 1;retinoblastoma-binding protein 3;transcription factor E2F1
Weitere Details:: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.

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