AKR1C3 Polyclonal Antibody

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£195.30

War £217.00

SKU:: E-AB-67236
Zusätzliche Namen:: AKR1C3,DD3,DDX,HA1753,HAKRB,HAKRe,HSD17B5,PGFS,hluPGFS
Anwendung:: WB, IF
Konzentration:: 1 mg/ml
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human, Mouse
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human AKR1C3 (NP_003730.4).
Uniprot:: P42330
Synonyme:: 17-beta-hydroxysteroid dehydrogenase type 5;3-alpha hydroxysteroid dehydrogenase, type II;3-alpha-HSD type II, brain;3-alpha-hydroxysteroid dehydrogenase type 2;aldo-keto reductase family 1 member C3;chlordecone reductase homolog HAKRb;DD3;DDX;dihydrodiol dehydrogenase 3;Dihydrodiol dehydrogenase type I;dihydrodiol dehydrogenase X;HA1753;HAKRB;HAKRe;hluPGFS;HSD17B5;indanol dehydrogenase;PGFS;prostaglandin F synthase;testosterone 17-beta-dehydrogenase 5;trans-1,2-dihydrobenzene-1,2-diol dehydrogenase;type IIb 3-alpha hydroxysteroid dehydrogenase
Weitere Details:: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene.

Versandbedingungen:: Blue Ice