MMP12 Polyclonal Antibody

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£195.30

War £217.00

SKU:: E-AB-67049
Zusätzliche Namen:: HME,ME,MME,MMP-12,MMP12
Anwendung:: WB
Konzentration:: 1 mg/ml
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: A synthetic peptide of human MMP12
Uniprot:: P39900
Synonyme:: HME;Macrophage elastase;macrophage metalloelastase;matrix metallopeptidase 12 (macrophage elastase);matrix metalloproteinase 12 (macrophage elastase);Matrix metalloproteinase-12;ME;MME;MMP-12
Weitere Details:: This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease degrades soluble and insoluble elastin. This gene may play a role in aneurysm formation and mutations in this gene are associated with lung function and chronic obstructive pulmonary disease (COPD). This gene is part of a cluster of MMP genes on chromosome 11.