E-AB-66448
PSENEN Polyclonal Antibody
Größe
£195.30
War £217.00
- SKU:
- E-AB-66448
- Zusätzliche Namen:
- MDS033,MSTP064,PEN-2,PEN2,PSENEN
- Anwendung:
- WB
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- A synthetic peptide of human PSENEN (NP_758844.1).
- Uniprot:
- Q9NZ42
- Synonyme:
- ACNINV2;gamma-secretase subunit PEN-2;hematopoietic stem/progenitor cells protein MDS033;MDS033;MSTP064;PEN-2;PEN2;presenilin enhancer 2 homolog;Presenilin enhancer protein 2
- Weitere Details:
- Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants.
- Versandbedingungen:
- Blue Ice