PRR5 Polyclonal Antibody

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£195.30

War £217.00

SKU:: E-AB-66447
Zusätzliche Namen:: FLJ20185k,PP610,PROTOR-1,PROTOR1,PRR5
Anwendung:: IF
Konzentration:: 1 mg/ml
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human PRR5 (NP_851850.1).
Uniprot:: P85299
Synonyme:: FLJ20185k;PP610;proline rich 5 (renal);proline-rich protein 5;protein observed with Rictor-1;PROTOR-1;PROTOR1;Rho GTPase activating protein 8
Weitere Details:: This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene.