DCN Polyclonal Antibody

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£195.30

War £217.00

SKU:: E-AB-66406
Zusätzliche Namen:: CSCD,DCN,DSPG2,Decorin,PG40,PGII,PGS2,SLRR1B,decorin
Anwendung:: IF
Konzentration:: 1 mg/ml
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human DCN (NP_598010.1).
Uniprot:: P07585
Synonyme:: bone proteoglycan II;CSCD;decorin;dermatan sulphate proteoglycans II;DSPG2;PG-S2;PG40;PGII;PGS2;proteoglycan core protein;SLRR1B;small leucine-rich protein 1B
Weitere Details:: This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients.