ABCB11 Polyclonal Antibody

Größe

£195.30

War £217.00

SKU:: E-AB-66326
Zusätzliche Namen:: ABC16,ABCB11,BRIC2,BSEP,PFIC-2,PFIC2,PGY4,SPGP
Anwendung:: IF
Konzentration:: 1 mg/ml
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: A synthetic peptide of human ABCB11
Uniprot:: O95342
Synonyme:: ABC member 16, MDR/TAP subfamily;ABC16;ATP-binding cassette sub-family B member 11;ATP-binding cassette, sub-family B (MDR/TAP), member 11;bile salt export pump;BRIC2;BSEP;PFIC-2;PFIC2;PGY4;progressive familial intrahepatic cholestasis 2;sister p-glycoprotein;SPGP
Weitere Details:: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy.