E-AB-66311
SNW1 Polyclonal Antibody
Größe
£195.30
War £217.00
- SKU:
- E-AB-66311
- Zusätzliche Namen:
- Bx42,FUN20,NCOA-62,PRPF45,Prp45,SKIIP,SKIP,SKIP1,SNW1
- Anwendung:
- IHC, WB, IF
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human SNW1 (NP_036377.1).
- Uniprot:
- Q13573
- Synonyme:
- Bx42;FUN20;homolog of Drosophila BX42;NCOA-62;nuclear protein SkiP;nuclear receptor coactivator NCoA-62;nuclear receptor coactivator, 62-kD;Prp45;PRPF45;SKI interacting protein;ski-interacting protein;SKIIP;SKIP;SKIP1;SNW domain-containing protein 1
- Weitere Details:
- This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. Alternative splicing results in multiple transcript variants.
- Versandbedingungen:
- Blue Ice