EP300 Polyclonal Antibody

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£195.30

War £217.00

SKU:: E-AB-65993
Zusätzliche Namen:: EP300,KAT3B,RSTS2,p300
Anwendung:: IHC
Konzentration:: 1 mg/ml
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human EP300 (NP_001420.2).
Uniprot:: Q09472
Synonyme:: E1A-associated protein p300;E1A-binding protein, 300kD;histone acetyltransferase p300;histone butyryltransferase p300;histone crotonyltransferase p300;KAT3B;MKHK2;p300;p300 HAT;protein 2-hydroxyisobutyryltransferase p300;protein lactyltransferas p300;protein propionyltransferase p300;RSTS2
Weitere Details:: This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.