WWOX Polyclonal Antibody

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£195.30

War £217.00

SKU:: E-AB-65948
Zusätzliche Namen:: D16S432E,EIEE28,FOR,FRA16D,HHCMA56,PRO0128,SCAR12,SDR41C1,WOX1,WWOX
Anwendung:: WB
Konzentration:: 1 mg/ml
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human WWOX (NP_057457.1).
Uniprot:: Q9NZC7
Synonyme:: D16S432E;DEE28;EIEE28;FOR;FRA16D;fragile site FRA16D oxidoreductase;HHCMA56;PRO0128;SCAR12;SDR41C1;short chain dehydrogenase/reductase family 41C member 1;WOX1;WW domain-containing oxidoreductase;WW domain-containing protein WWOX
Weitere Details:: This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants.