SMG7 Polyclonal Antibody

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£195.30

War £217.00

SKU:: E-AB-65287
Zusätzliche Namen:: C1orf16,EST1C,SGA56M,SMG7
Anwendung:: WB
Konzentration:: 1 mg/ml
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human SMG7 (NP_963863.2).
Uniprot:: Q92540
Synonyme:: breast cancer-associated antigen SGA-56M;C1orf16;EST1 telomerase component homolog C;EST1-like protein C;EST1C;ever shorter telomeres 1C;protein SMG7;SGA56M;SMG-7 homolog;smg-7 homolog, nonsense mediated mRNA decay factor
Weitere Details:: This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD), a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms.