PTPRN2 Polyclonal Antibody

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£195.30

War £217.00

SKU:: E-AB-65105
Zusätzliche Namen:: IA-2beta,IAR,ICAAR,PTPRN2,PTPRP,R-PTP-N2
Anwendung:: IHC
Konzentration:: 1 mg/ml
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human PTPRN2 (NP_570858.2).
Uniprot:: Q92932
Synonyme:: IA-2beta;IAR;IAR/receptor-like protein-tyrosine phosphatase;ICAAR;islet cell autoantigen-related protein;phogrin;protein tyrosine phosphatase receptor pi;protein tyrosine phosphatase, receptor type, N polypeptide 2;PTPRP;R-PTP-N2;receptor-type tyrosine-protein phosphatase N2;tyrosine phosphatase IA-2 beta
Weitere Details:: This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants.