E-AB-64966
TNFRSF25 Polyclonal Antibody
Größe
£195.30
War £217.00
- SKU:
- E-AB-64966
- Zusätzliche Namen:
- APO-3,DDR3,DR3,LARD,TNFRSF12,TNFRSF25,TR3,TRAMP,WSL-1,WSL-LR
- Anwendung:
- IF
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human TNFRSF25 (NP_683866.1).
- Uniprot:
- Q93038
- Synonyme:
- APO-3;apoptosis inducing receptor;apoptosis-inducing receptor AIR;apoptosis-mediating receptor DR3;apoptosis-mediating receptor TRAMP;DDR3;death domain receptor 3 soluble form;Death receptor 3;death receptor beta;DR3;GEF720;Guanine nucleotide exchange factor 720;LARD;lymphocyte-associated receptor of death;PH domain-containing family G member 5;Pleckstrin homology domain-containing family G member 5;PLEKHG5;Protein WSL;protein WSL-1;TNFRSF12;TR3;TRAMP;tumor necrosis factor receptor superfamily member 25;tumor necrosis factor receptor superfamily, member 12 (translocating chain-association membrane protein);WSL-1;WSL-LR
- Weitere Details:
- The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation.
- Versandbedingungen:
- Blue Ice