CRACR2A Polyclonal Antibody

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£195.30

War £217.00

SKU:: E-AB-64839
Zusätzliche Namen:: CRACR2A,EFCAB4B
Anwendung:: IHC, WB
Konzentration:: 1 mg/ml
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human, Mouse
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human CRACR2A (NP_001138430.1).
Uniprot:: Q9BSW2
Synonyme:: Ca2+ release-activated Ca2+ (CRAC) channel regulator 2A;calcium release-activated calcium channel regulator 2A;Calcium release-activated channel regulator 2A;CRAC channel regulator 2A;CRAC regulator 2A;EF-hand calcium binding domain 4B;EF-hand calcium-binding domain-containing protein 4B;EFCAB4B;RAB46;ras-related protein Rab-46
Weitere Details:: Ca2+-binding protein that plays a key role in store-operated Ca2+entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca2+resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.