PIDD Polyclonal Antibody

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£195.30

War £217.00

SKU:: E-AB-63806
Zusätzliche Namen:: LRDD,PIDD,PIDD1
Anwendung:: IHC, WB, IF
Konzentration:: 1 mg/ml
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human PIDD (NP_665893.2).
Uniprot:: Q9HB75
Synonyme:: leucine-rich repeat and death domain-containing protein;leucine-rich repeats and death domain containing;LRDD;p53-induced death domain-containing protein 1;p53-induced protein with a death domain;PIDD
Weitere Details:: The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants.