MAPRE1 Polyclonal Antibody

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£195.30

War £217.00

SKU:: E-AB-63725
Zusätzliche Namen:: EB1,MAPRE1
Anwendung:: IF
Konzentration:: 1 mg/ml
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human MAPRE1 (NP_036457.1).
Uniprot:: Q15691
Synonyme:: adenomatous polyposis coli-binding protein EB1;APC-binding protein EB1;EB1;end-binding protein 1;microtubule-associated protein RP/EB family member 1
Weitere Details:: The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family.