E-AB-62582
STRA13 Polyclonal Antibody
Größe
£195.30
War £217.00
- SKU:
- E-AB-62582
- Zusätzliche Namen:
- CENP-X,CENPX,D9,FAAP10,MHF2,STRA13
- Anwendung:
- WB
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human STRA13 (NP_659435.2).
- Uniprot:
- A8MT69
- Synonyme:
- CENP-X;centromere protein X;D9;FAAP10;FANCM associated histone fold protein 2;FANCM-associated histone fold protein 2;FANCM-interacting histone fold protein 2;Fanconi anemia-associated polypeptide of 10 kDa;MHF2;retinoic acid-inducible gene D9 protein homolog;stimulated by retinoic acid 13 homolog;stimulated by retinoic acid gene 13 protein homolog;STRA13
- Weitere Details:
- DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (PubMed:20347428, PubMed:20347429). In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure.
- Versandbedingungen:
- Blue Ice