SAV1 Polyclonal Antibody

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£195.30

War £217.00

SKU:: E-AB-62507
Zusätzliche Namen:: SAV,SAV1,WW45,WWP4
Anwendung:: WB
Konzentration:: 1 mg/ml
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human, Mouse
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human SAV1 (NP_068590.1).
Uniprot:: Q9H4B6
Synonyme:: 1700040G09Rik;45 kDa WW domain protein;hWW45;protein salvador homolog 1;salvador homolog 1;SAV;WW domain-containing adaptor 45;WW45;WWP4
Weitere Details:: WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor.