DMAP1 Polyclonal Antibody

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£195.30

War £217.00

SKU:: E-AB-62489
Zusätzliche Namen:: DMAP1,DNMAP1,DNMTAP1,EAF2,MEAF2,SWC4
Anwendung:: WB
Konzentration:: 1 mg/ml
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human DMAP1 (NP_061973.1).
Uniprot:: Q9NPF5
Synonyme:: DNA methyltransferase 1-associated protein 1;DNMAP1;DNMT1 associated protein 1;DNMTAP1;EAF2;MEAF2;SWC4
Weitere Details:: This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.