(KO Validated) CBX3 Polyclonal Antibody

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£210.60

War £234.00

SKU:: E-AB-62382
Zusätzliche Namen:: CBX3,HECH,HP1-GAMMA,HP1Hs-gamma
Anwendung:: IHC, WB, IF
Konzentration:: 1 mg/ml
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human CBX3 (NP_009207.2).
Uniprot:: Q13185
Synonyme:: chromobox homolog 3 (HP1 gamma homolog, Drosophila);chromobox protein homolog 3;HECH;heterochromatin protein 1 homolog gamma;heterochromatin protein HP1 gamma;heterochromatin-like protein 1;HP1 gamma homolog;HP1-GAMMA;HP1Hs-gamma;modifier 2 protein
Weitere Details:: At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.