E-AB-62240
TGFB2 Polyclonal Antibody
Größe
£211.50
War £235.00
- SKU:
- E-AB-62240
- Zusätzliche Namen:
- G-TSF,LDS4,TGF-beta2,TGFB2
- Anwendung:
- WB
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human TGFB2 (NP_001129071.1).
- Uniprot:
- P61812
- Synonyme:
- BSC-1 cell growth inhibitor;cetermin;G-TSF;glioblastoma-derived T-cell suppressor factor;LDS4;polyergin;prepro-transforming growth factor beta-2;TGF-beta2;transforming growth factor beta-2 proprotein
- Weitere Details:
- This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1,7)(q41,p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified.
- Versandbedingungen:
- Blue Ice