CDKN2C Polyclonal Antibody

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£195.30

War £217.00

SKU:: E-AB-61784
Zusätzliche Namen:: CDKN2C,INK4C,p18,p18-INK4C
Anwendung:: IHC, IF
Konzentration:: 1 mg/ml
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human CDKN2C (NP_523240.1).
Uniprot:: P42773
Synonyme:: CDK6 inhibitor p18;cyclin-dependent inhibitor;cyclin-dependent kinase 4 inhibitor C;Cyclin-dependent kinase 6 inhibitor;cyclin-dependent kinase 6 inhibitor p18;cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4);INK4C;p18;p18-INK4C;p18-INK6
Weitere Details:: The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.