ACVR2A Polyclonal Antibody

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£195.30

War £217.00

SKU:: E-AB-60537
Zusätzliche Namen:: ACTRII,ACVR2,ACVR2A
Anwendung:: IHC, IF
Konzentration:: 1 mg/ml
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human ACVR2A (NP_001607.1).
Uniprot:: P27037
Synonyme:: activin A receptor, type IIA;Activin receptor type IIA;activin receptor type-2A;ACTRII;ACVR2
Weitere Details:: This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene.