(KO Validated) HuR / ELAVL1 Polyclonal Antibody

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£210.60

War £234.00

SKU:: E-AB-60367
Zusätzliche Namen:: ELAV1,ELAVL1,HUR,HuR / ELAVL1,Hua,MelG
Anwendung:: IHC, WB, IF
Konzentration:: 1 mg/ml
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human HuR / ELAVL1 (NP_001410.2).
Uniprot:: Q15717
Synonyme:: ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R);ELAV-like protein 1;ELAV1;embryonic lethal, abnormal vision, drosophila, homolog-like 1;Hu antigen R;hu-antigen R;Hua;HUR;MelG
Weitere Details:: The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy.