E-AB-60323
NQO1 Polyclonal Antibody
Größe
£211.50
War £235.00
- SKU:
- E-AB-60323
- Zusätzliche Namen:
- DHQU,DIA4,DTD,NMOR1,NMORI,NQO1,QR1
- Anwendung:
- WB
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- A synthetic peptide of human NQO1 (NP_000894.1).
- Uniprot:
- P15559
- Synonyme:
- azoreductase;DHQU;DIA4;diaphorase (NADH/NADPH) (cytochrome b-5 reductase);diaphorase-4;dioxin-inducible 1;DT-diaphorase;DTD;menadione reductase;NAD(P)H dehydrogenase [quinone] 1;NAD(P)H dehydrogenase, quinone 1;NAD(P)H:menadione oxidoreductase 1;NAD(P)H:Quinone acceptor oxidoreductase type 1;NAD(P)H:quinone oxidoreductase 1;NAD(P)H:quinone oxireductase;NMOR1;NMORI;phylloquinone reductase;QR1;quinone reductase 1
- Weitere Details:
- This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
- Versandbedingungen:
- Blue Ice