E-AB-53550
XAB2 Polyclonal Antibody
Größe
£106.20
War £118.00
- SKU:
- E-AB-53550
- Zusätzliche Namen:
- 0610041O14Rik,AV025587,Adapter protein ATH-55,Ath55,Crn related protein kim1 ,DKFZp762C1015,HCNP,HCNP protein,HCRN,KIAA1177,NTC90,PP3898,Pre-mRNA-splicing factor SYF1,Protein HCNP,RNA splicing factor,SY,SYF1,adapter protein ATH 55,crn-related protein kim1
- Anwendung:
- IHC, WB
- Konzentration:
- 0.4 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human XAB2
- Uniprot:
- Q9HCS7
- Synonyme:
- crn-related protein kim1;HCNP;HCRN;NTC90;pre-mRNA-splicing factor SYF1;Protein HCNP;SYF1;SYF1 homolog, RNA splicing factor;SYF1 pre-mRNA-splicing factor;XPA-binding protein 2
- Weitere Details:
- HCNP, also known as XAB2 (Xeroderma pigmentosum group A (XPA) binding protein 2), HCRN, SYF1 or NTC90, is a nuclear protein that participates in transcription, transcription-coupled repair (TCR) and pre-mRNA splicing. It contains fifteen tetratricopeptide repeat motifs and associates with nucleotide excision repair machinery. More specifically, HCNP associates with Cockayne syndrome group A and B proteins (CSA and CSB), RNA Polymerase II (Pol II) and XPA in response to DNA damage and is believed to function in the TCR pathway. HCNP also functions as an essential component of a pre-mRNA splicing complex of the spliceosome (composed of AQR (aquarius), PRP19, CCDC16, HCNP, ISY1 and Cyclophilin E) and is required for proper RNA synthesis in the cell. In addition, HCNP functions as a component of the RAR corepressor complex with RAR and HDAC3 and exhibits an inhibitory effect on ATRA-induced cell differentiation. This suggests that HCNP may function as useful target in cancer therapy.
- Versandbedingungen:
- Blue Ice