E-AB-53523
PFKFB3 Polyclonal Antibody
Größe
£106.20
War £118.00
- SKU:
- E-AB-53523
- Zusätzliche Namen:
- IPFK2,PFK/FBPase 3,PFK2,Renal Carcinoma Antigen NY-REN-56
- Anwendung:
- WB
- Konzentration:
- 0.5 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human PFKFB3
- Uniprot:
- Q16875
- Synonyme:
- 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase;6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3;6PF-2-K/Fru-2,6-P2ase 3;6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme;fructose-6-phosphate,2-kinase/fructose-2, 6-bisphosphatase;inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase;iPFK-2;IPFK2;PFK/FBPase 3;PFK2;renal carcinoma antigen NY-REN-56
- Weitere Details:
- The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
- Versandbedingungen:
- Blue Ice