E-AB-53198
VGLL1 Polyclonal Antibody
Größe
£106.20
War £118.00
- SKU:
- E-AB-53198
- Zusätzliche Namen:
- Protein TONDU,TDU,TONDU,Transcription cofactor vestigial like protein 1,Transcription cofactor vestigial-like protein 1,VGL1,VGLL1,Vestigial like 1,Vgl-1,Vgll1,vestigial like 1 homolog (Drosophila)
- Anwendung:
- WB
- Konzentration:
- 2 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human VGLL1
- Uniprot:
- Q99990
- Synonyme:
- Protein TONDU;TDU;TONDU;transcription cofactor vestigial-like protein 1;vestigial like 1;vgl-1;VGL1;WUGSC:H_GS188P18.1b
- Weitere Details:
- The protein encoded by this gene binds proteins of the TEA domain family of transcription factors (TEFs) through the Vg (vestigial) homology region found in its N-terminus. It may thus function as a specific coactivator for the mammalian TEFs. TDU interacted directly with the TEA domain family member, TEF1, and deletion of the Vg homology region abolished the interaction. The TDU-TEF1 dimer activated a reporter plasmid, and expression of TDU in Drosophila rescued loss of Vg function. The interaction was stronger in cardiac myocytes, suggesting a myocyte-specific factor may participate in the interaction. Vgll1 was weakly active in driving expression of a reporter gene from the mouse skeletal muscle alpha-actin promoter, and Vgll1 could partially reverse the inhibitory effect of TEF1 in this assay.
- Versandbedingungen:
- Blue Ice