E-AB-53007
SRPK2 Polyclonal Antibody
Größe
£106.20
War £118.00
- SKU:
- E-AB-53007
- Zusätzliche Namen:
- complete cds,Human serine kinase SRPK2 mRNA,SFRS protein kinase 2,SFRSK2 ,SR protein specific kinase ,Serine kinase SRPK2,Serine/arginine rich protein specific kinase 2,Serine/arginine-rich protein-specific kinase 2,Serine/threonine protein kinase SRPK2
- Anwendung:
- IHC
- Konzentration:
- 0.96 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Fusion protein of human SRPK2
- Uniprot:
- P78362
- Synonyme:
- serine kinase SRPK2;serine/arginine-rich protein-specific kinase 2;serine/arginine-rich splicing factor kinase 2;serine/threonine-protein kinase SRPK2;SFRS protein kinase 2;SFRSK2;SR protein kinase 2;SR-protein-specific kinase 2;SRSF protein kinase 2
- Weitere Details:
- Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles.
- Versandbedingungen:
- Blue Ice