E-AB-40588
GRP78 Polyclonal Antibody
Größe
£120.60
War £134.00
- SKU:
- E-AB-40588
- Zusätzliche Namen:
- GRP-78, HSP70 family protein 5, HSPA5, Heat shock protein family A member 5, Immunoglobulin heavy chain-binding protein,BiP
- Anwendung:
- WB
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS with 0.05% Proclin300, 1% protective protein and 50% glycerol, pH7.4
- Immunogen:
- Recombinant Human GRP78 protein expressed by E.coli.
- Uniprot:
- P11021
- Synonyme:
- 78 kDa glucose-regulated protein;binding-immunoglobulin protein;BIP;endoplasmic reticulum chaperone BiP;endoplasmic reticulum lumenal Ca(2+)-binding protein grp78;epididymis secretory sperm binding protein Li 89n;glucose-regulated protein, 78kDa;GRP78;heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa);heat shock protein 70 family protein 5;heat shock protein family A member 5;HEL-S-89n;HSP70 family protein 5;immunoglobulin heavy chain-binding protein
- Weitere Details:
- GRP78 (Glucose-regulated protein 78 kDa, also BiP and HSPA5) is a 72 kDa member of the heat shock protein 70 family of proteins. Intracellularly, GRP78 is an endoplasmic reticulum chaperone that participates in protein folding, extracellularly, it induces IL-10 production from T cells and interacts with Cripto to block TGF-beta signaling. Human GRP78 precursor is 654 amino acids (aa) in length. It contains an 18 aa signal sequence and a 636 aa mature region that shows a hydantoinase A region (aa 145-245) and a C-terminal KDEL motif that is present on intracellular GRP78, but absent on secreted GRP78. There is alternative splicing in the signal sequence (aa 1-10), and multiple single aa substitituion. Over aa 1-654, human GRP78 is more than 97% aa identical to mouse and rat GRP78.
- Versandbedingungen:
- Blue Ice