CXCL12/SDF1 Polyclonal Antibody

Größe

£120.60

War £134.00

SKU:: E-AB-40578
Zusätzliche Namen:: SDF-1,Cxcl12
Anwendung:: WB
Konzentration:: 1 mg/ml
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human, Mouse, Rat
Buffer:: PBS with 0.05% Proclin300, 1% protective protein and 50% glycerol, pH7.4
Immunogen:: Recombinant Rat CXCL12 protein expressed by E.coli.
Uniprot:: Q9QZD1
Synonyme:: chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1);SDF-1 gamma;Sdf1;stromal cell-derived factor 1;stromal cell-derived factor-1 gamma
Weitere Details:: The stromal cell derived factor 1 (SDF1/CXCL12) is a small, pro-inflammatory chemoattractant cytokine that regulates leukocyte trafficking through interactions with its cognate 7-transmembrane G protein-coupled receptors. The SDF1/CXCL12 receptor, CXCR4, also serves as a coreceptor for the entry of human immunodeficiency virus into target cells. SDF1/CXCL12 may regulate homing and maintenance of CXCR4-expressing stem or progenitor cells, including embryonic and many somatic stem cells. Many cancer cells express CXCR4, suggesting that SDF1/CXCL12 plays a role in cancer metastasis. Alternative splicing and differential processing during maturation produce a pair of SDF1/CXCL12 isoforms (SDF1/CXCL12A Alpha and SDF1/CXCL12B Beta) that have different properties and biological activities. Additional isoforms of SDF1/CXCL12 have been reported.