E-AB-40288
BRCA2 Polyclonal Antibody
Größe
£120.60
War £134.00
- SKU:
- E-AB-40288
- Zusätzliche Namen:
- BRCC 2, BROVCA2, Breast and ovarian cancer susceptibility gene early onset antibody, FACD, FAD 1, FANCB, GLM3,BRCA 2
- Anwendung:
- IHC, WB, IF
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Rat
- Buffer:
- PBS with 0.05% Proclin300, 1% protective protein and 50% glycerol, pH7.4
- Immunogen:
- Recombinant Human Breast cancer type 2 susceptibility protein
- Uniprot:
- P51587
- Synonyme:
- BRCA1/BRCA2-containing complex, subunit 2;BRCC2;breast and ovarian cancer susceptibility gene, early onset;breast and ovarian cancer susceptibility protein 2;breast cancer 2 tumor suppressor;breast cancer 2, early onset;breast cancer type 2 susceptibility protein;BROVCA2;FACD;FAD;FAD1;FANCD;FANCD1;Fanconi anemia group D1 protein;GLM3;mutant BRCA2;PNCA2;truncated BRCA2 DNA repair associated;truncated BRCA2 DNA repair-associated protein;truncated breast cancer 2;truncated DNA repair-associated BRCA2;truncated DNA repair-associated protein;XRCC11
- Weitere Details:
- Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.
- Versandbedingungen:
- Blue Ice